This paper reviews the literature concerning safety management interventions, that have been effective in reducing injury outcomes in occupational health and safety (OHS) and road safety, and assesses their applicability to reducing crash and injury outcomes in heavy vehicle transport. The operational and management characteristics that were associated with reduced crash and injury risk included: safety training, management commitment, scheduling or journey planning, size of organisation or freight type, worker participation, incentives and safety or return to work policies. Other characteristics that might be associated with lower incident and injury rates were risk analysis/corrective actions, prior safety violations, crashes or incidents, vehicle conditions or physical work environment, vehicle technologies, recruitment and retention, pay and remuneration systems, communications/ support, safety or quality management accreditation, financial performance, and worker characteristics and attitudes. The review also highlighted gaps in the literature requiring further research.